can you hear me

   As we grow older, neurons – the nerve cells that deliver commands from our brains – have to “speak” more loudly to get the attention of our muscles to move, according to researcher Christopher Knight, an assistant professor of Health Sciences at the University of Delaware.
   “As a result of age-related changes in muscle and neurons, elderly people are often frustrated by poor control during precision tasks, and slowed physical responses contribute to falls as people grow older,” Knight said.
   Knight and co-author Gary Kamen, who directs the Exercise Neuroscience Laboratory at the University of Massachusetts, recently published the results of a study on motor-unit firing rates in the Journal of Applied Physiology, and Knight is now beginning a new project focusing on motor-control mechanisms in the elderly.
   The ultimate goal of the research, Knight said, is to improve movement quality in the elderly, as well as patients with disorders such as cerebral palsy or multiple sclerosis, or who are recovering from strokes.

HOW IT WORKS!

Every move you make is made possible through a communications network involving the brain at the command centre, the spinal cord, billions upon billions of nerve cells, and thousands of muscle fibres.
   “Muscles are the driving force behind our movements,” Knight said. “Every time they get a command from the neurons, the muscle fibres contract. In the generation of muscular force, the smallest controllable unit consists of an individual neuron and the muscle fibres it stimulates. We believe that our research is very important to our understanding of motor-control mechanisms in general and impaired control in patient populations.”
   Shedding light on the communication between neurons and muscles, and how it changes as we age, may lie right at our fingertips, according to Knight.
   Using an apparatus he and his students made, Knight has been examining muscular force on a very small scale in the index finger, specifically, the first dorsal interosseous muscle. Located between the index finger and the thumb, this muscle contains 120 “motor units”– 120 individual neurons, or nerve cells, and the muscle fibres they activate.
   “It’s a relatively simple muscle, so you get to see more of a one-to-one relationship between the activity of the neurons and the resulting muscular force,” Knight said.
   Twenty-three subjects, ranging from 18 to 88 years of age, participated in Knight’s recent study.
   In a virtually painless procedure, a small needlelike electrode with four tiny wires was embedded in the muscle of an index finger of each subject. The electrode was hooked up to a PC to record the electrical impulses as they travel from neurons to the muscles. As the index finger was held steady in a small harness, each subject was asked to use the finger to follow the outline of a sinusoidal curve, with its peaks and valleys, on a computer screen.
   “More force – which is indicated by a corresponding higher firing rate of neurons – is exerted just before you begin the upturn toward one peak and then it eases off again in the downturn toward a valley,” Knight noted.
   Once recordings were completed at one site in the muscle, the electrode was repositioned to sample from other motor units within the muscle.
   Knight and students Dhiraj Poojari, Maria Bellumori and Christopher Martens then analysed the firing-rate data for frequency and amplitude in a tedious process that Knight hopes to automate in the future through a software program that will help sort out the bang-bang-like “doublets” – the brief periods when the neurons fire faster, from slower periods of activity.

EXERCISE MIGHT BE THE KEY

The results showed lower firing rates among older subjects versus younger subjects – a diminished ability of the muscle fibres to “hear” and respond to the neurons’ commands.
   “The repeated contraction of muscles is essential to movements such as walking,” Knight said. “However, our muscles have a reduced capacity to contract or ‘twitch’ as we grow older. We lose fasttwitch muscle fibres as we age.”
   However, there are steps we can take to preserve this critical motor capacity, according to Knight.
   “After power training with weights, we see an increase in firing rates,” Knight said. “For safety, we’re commonly advised to do things slowly, but it’s important to also do some fast exercises. You need a fast movement to prevent a fall. Even in the frail elderly, it is possible to use exercise bands for resistance to improve the speed of movement.”
   Knight has always been interested in how the body adapts to exercise. According to Knight, “Exercise is still the means for improvement, and aging is a process that unites us all.”

CAN YOU HEAR ME ?